People suffering from chronic nerve pain, anxiety, epilepsy, or insomnia may be prescribed Pregabalin and Zopiclone. While both medications are effective for their respective conditions, mixing them can be risky.

Many people wonder, “Can I take Pregabalin with Zopiclone?” This article provides a detailed breakdown of the drug interactions, side effects, risks, and safer alternatives to help you make an informed decision.

Understanding Pregabalin and Zopiclone: What Are They?

Before exploring their interaction, let’s understand what each medication does.

What Is Pregabalin?

Pregabalin is a medication commonly used for:

• Nerve pain relief (neuropathic pain)
• Generalized anxiety disorder (GAD)
• Epilepsy and seizures

Pregabalin works by calming overactive nerve signals, reducing pain, anxiety, and seizures. It is classified as an anticonvulsant but is also widely prescribed for anxiety and nerve-related pain.

🔹 Brand names of Pregabalin:

• Lyrica
• Nervigesic
• Alzain

🔹 Common side effects of Pregabalin:

• Drowsiness
• Dizziness
• Weight gain
• Dry mouth

What Is Zopiclone?

Zopiclone is a prescription sleeping pill used to treat short-term insomnia. It helps people fall asleep faster and improves sleep quality.

Unlike benzodiazepines, Zopiclone is classified as a non-benzodiazepine sedative-hypnotic. However, it still acts on GABA receptors in the brain, producing sedative effects.

🔹 Brand names of Zopiclone:

• Imovane
• Zimovane
• Dopareel

🔹 Common side effects of Zopiclone:

• Drowsiness
• Bitter/metallic taste
• Dry mouth
• Headache

Can You Take Pregabalin and Zopiclone Together?

Combining Pregabalin and Zopiclone can be risky because both drugs slow down brain activity and affect the central nervous system (CNS).

When taken together, they can increase sedation and drowsiness, leading to:
✅ Extreme drowsiness
✅ Dizziness and confusion
✅ Impaired thinking and memory
✅ Slow breathing rate (respiratory depression)
✅ Increased risk of falls (especially in older adults)

Medical Advice on Taking Pregabalin with Zopiclone

Doctors may prescribe both medications together in some cases. However, this is usually done at lower doses and under strict supervision to prevent dangerous side effects.

⚠️ DO NOT take both medications together without a doctor’s prescription.

Potential Side Effects of Taking Pregabalin and Zopiclone Together

If taken together, Pregabalin and Zopiclone may cause the following side effects:

Mild Side Effects:

🔹 Dizziness
🔹 Daytime drowsiness
🔹 Blurry vision
🔹 Headache

Serious Side Effects (Seek Medical Help Immediately):

⚠️ Slow or shallow breathing
⚠️ Extreme confusion or disorientation
⚠️ Hallucinations
⚠️ Loss of coordination (risk of falls)
⚠️ Fainting or loss of consciousness

🚨 Overdose Risk: Combining Pregabalin and Zopiclone can increase the risk of overdose, which may lead to coma or respiratory failure. If someone shows signs of overdose, call emergency services immediately.

Who Should NOT Take Pregabalin and Zopiclone Together?

🚫 Certain individuals face higher risks when taking these two medications together, including:

❌ Older adults – Increased risk of falls and cognitive impairment.
❌ People with breathing problems – Such as asthma, COPD, or sleep apnea.
❌ Individuals with a history of substance abuse – Higher addiction risk.
❌ People with liver or kidney disease – The body may struggle to clear these drugs properly.

Pregnant or breastfeeding women should also avoid these medications unless prescribed under strict medical guidance.

Also Read: How Many Zopiclone Can I Take in One Night? Safe Dosage Guide

Safer Alternatives to Zopiclone and Pregabalin

If you are looking for safer options to manage insomnia, nerve pain, or anxiety, consider the following alternatives:

Alternatives for Insomnia (Instead of Zopiclone)

✅ Melatonin supplements – Helps regulate sleep cycles naturally.
✅ Cognitive Behavioral Therapy for Insomnia (CBT-I) – A non-medication approach proven to treat insomnia.
✅ Lifestyle changes – Avoid caffeine and screen time before bed, and establish a consistent sleep schedule.

Alternatives for Anxiety and Nerve Pain (Instead of Pregabalin)

✅ Gabapentin – Similar to Pregabalin but with different side effect profiles.
✅ Duloxetine or Amitriptyline – Alternative medications for nerve pain.
✅ Herbal supplements – Such as Valerian root, Ashwagandha, and Magnesium, which promote relaxation.

How to Take Pregabalin and Zopiclone Safely (If Prescribed Together)?

If your doctor has prescribed both medications, follow these safety tips:

1️⃣ Take the lowest effective dose – Never increase your dosage without medical advice.
2️⃣ Avoid alcohol and other sedatives – Mixing these drugs with alcohol can be life-threatening.
3️⃣ Take them at different times – Spacing out doses can help reduce side effects.
4️⃣ Monitor for breathing problems – Watch out for slow or shallow breathing.
5️⃣ Never abruptly stop taking them – Gradual tapering is required to avoid withdrawal symptoms.

FAQs: Taking Pregabalin and Zopiclone Together

1. Can I take Zopiclone after Pregabalin?

Yes, but only if prescribed by a doctor. Taking them close together increases the risk of excessive sedation.

2. What happens if I overdose on Pregabalin and Zopiclone?

Overdosing can lead to severe sedation, slowed breathing, coma, or even death. Seek emergency medical help immediately.

3. Can I take Pregabalin and Zopiclone long-term?

Both medications are generally not recommended for long-term use due to risks of dependence and withdrawal symptoms.

4. Can I drive after taking Pregabalin and Zopiclone?

No. Both drugs can cause drowsiness and impaired coordination, making driving dangerous.

5. What are the safest sleeping aids if I take Pregabalin?

Melatonin, meditation, and CBT-I (Cognitive Behavioral Therapy for Insomnia) are safer options.

Final Thoughts: Should You Take Pregabalin with Zopiclone?

Taking Pregabalin and Zopiclone together can be risky due to their sedative effects on the central nervous system. While some doctors prescribe them together, it should only be done under medical supervision.

🔹 Key takeaways:
✔️ Always follow your doctor’s dosage recommendations.
✔️ Be aware of potential side effects and overdose risks.
✔️ Consider safer alternatives if you experience severe side effects.

If you experience breathing difficulties, confusion, or extreme drowsiness, seek emergency medical attention immediately.

Also Read: How Long Does Zopiclone Take to Work for Sleep?