Zopiclone is a widely prescribed medication used to treat short-term insomnia. While it’s effective in helping people fall and stay asleep, many users have raised concerns about unexpected side effects — one of the most commonly asked questions being: “Can Zopiclone cause weight gain?”

In this article, we’ll explore the possible connection between Zopiclone and weight changes, examine clinical evidence, and offer guidance for those concerned about their weight while using sleep aids.

What Is Zopiclone?

Zopiclone is a non-benzodiazepine hypnotic drug primarily used to treat insomnia. It is available under several brand names such as Imovane, Zimovane, and generic versions. Zopiclone works by enhancing the activity of GABA (gamma-aminobutyric acid) in the brain — a neurotransmitter that promotes relaxation and sleep.

Doctors typically prescribe Zopiclone for short-term use due to its risk of dependency and reduced effectiveness over time.

Common Side Effects of Zopiclone

Most people tolerate Zopiclone well, but like all medications, it comes with a range of side effects. The most commonly reported include:

• Drowsiness and fatigue
• Metallic or bitter taste
• Dry mouth
• Dizziness
• Memory issues (especially with long-term use)
• Headaches

While these are well-documented, weight gain is not officially listed as a primary side effect, which leads to the question: why do some people report gaining weight?

Is Weight Gain a Known Side Effect of Zopiclone?

Zopiclone is not directly associated with weight gain in clinical trials or drug monographs. However, anecdotal evidence from patients suggests that some individuals experience weight changes, especially with prolonged use. The absence of direct evidence does not mean the risk doesn’t exist — it simply hasn’t been significantly studied or proven.

Some users report:

• Increased appetite, particularly in the evening
• Reduced motivation to exercise
• Fluid retention or bloating

These experiences are not universal and could be influenced by various personal health or lifestyle factors.

Also Read: What Are the Most Common Signs Indicating I Might Have a Sleep Disorder?

How Sleep Medications May Indirectly Contribute to Weight Gain

Even if Zopiclone doesn’t directly cause weight gain, several indirect factors could play a role:

1. Improved Sleep and Appetite Regulation

Better sleep can lead to improved appetite. For some, the return of a regular appetite can feel like weight gain if calorie consumption increases without added activity.

2. Hormonal Fluctuations

Sleep affects hormones like ghrelin and leptin, which regulate hunger and satiety. Disrupted sleep can increase ghrelin (hunger hormone) and reduce leptin (satiety hormone), potentially leading to weight gain over time.

3. Decreased Activity

Residual drowsiness or fatigue, especially in the mornings, may discourage physical activity, leading to a more sedentary lifestyle.

4. Nighttime Eating Patterns

If Zopiclone causes early morning awakenings or grogginess, some people may develop poor nighttime eating habits, leading to gradual weight gain.

Other Factors That Could Influence Weight Gain While Taking Zopiclone

• Co-prescribed medications: Drugs like antidepressants, antipsychotics, or mood stabilizers often used alongside Zopiclone may contribute to weight gain.
• Mental health conditions: Insomnia is often linked to anxiety or depression, both of which can affect eating habits and metabolism.
• Age and metabolism: As metabolism slows with age, weight gain may occur regardless of medication.
• Diet and exercise: Poor lifestyle habits may be mistakenly attributed to medication.

What to Do If You’re Experiencing Weight Gain on Zopiclone

If you suspect that Zopiclone is affecting your weight, consider the following:

✔ Track Your Progress

Maintain a journal tracking:

• Your weight
• Sleep quality
• Physical activity
• Appetite levels

This can help identify any patterns or triggers.

✔ Consult Your Healthcare Provider

Don’t stop or change the dosage without consulting your doctor. Your physician may:

• Adjust the dosage
• Recommend alternative treatments (e.g., melatonin, CBT-I, or herbal remedies)
• Evaluate for other contributing factors

✔ Improve Sleep Naturally

Explore non-pharmacological treatments:

• Cognitive Behavioral Therapy for Insomnia (CBT-I)
• Sleep hygiene practices (consistent bedtime, no screens, etc.)
• Regular physical activity

When Should You See a Doctor?

Seek medical advice if:

• You experience rapid or unexplained weight gain
• You notice swelling or fluid retention
• You feel persistently drowsy or fatigued during the day
• You’re concerned about dependency or long-term side effects

Early intervention helps prevent further complications and allows your provider to find a safer, more effective solution.

Conclusion

While Zopiclone is not directly linked to weight gain, certain indirect effects — such as increased appetite, hormonal shifts, or reduced activity — may contribute to weight changes in some users.

If you’re concerned about your weight while using Zopiclone, it’s essential to take a holistic approach: monitor lifestyle habits, consult a healthcare provider, and consider alternatives that promote both healthy sleep and metabolic balance.

FAQs About Zopiclone and Weight Gain

❓ Can Zopiclone increase appetite?

Not directly, but improved sleep or sedation may affect appetite-regulating hormones.

❓ How can I avoid weight gain on Zopiclone?

Maintain an active lifestyle, eat a balanced diet, and consider natural sleep remedies if advised by your doctor.

❓ Are there weight-neutral alternatives to Zopiclone?

Yes. Melatonin, CBT-I, or some herbal supplements (like valerian root) may offer sleep benefits without affecting weight.

❓ Should I stop Zopiclone if I gain weight?

No. Always speak with your doctor before stopping or adjusting any prescription medication.

Also Red: What Are the Most Common Signs Indicating I Might Have a Sleep Disorder?