Zopiclone is one of the most commonly prescribed medications for short-term insomnia in the UK and across the world. Known for its fast-acting sedative properties, Zopiclone can help those suffering from sleeplessness fall asleep faster and stay asleep longer. But as with any prescription medication, understanding the safe dosage is crucial—especially when it comes to daily limits and avoiding accidental overdose.

In this guide, we’ll cover everything you need to know about the maximum recommended dose of Zopiclone in a 24-hour period, its side effects, overdose risks, and how to use it responsibly.

What is Zopiclone?

Zopiclone is a non-benzodiazepine hypnotic medication classified under the group commonly known as “Z-drugs.” It works by enhancing the activity of a neurotransmitter called GABA (gamma-aminobutyric acid) in the brain, which produces a calming effect and induces sleep.

Zopiclone is typically prescribed for short-term treatment of sleep problems like:

• Trouble falling asleep (sleep-onset insomnia)
• Waking up during the night
• Early morning awakenings
• Poor sleep quality

Common Dosage Forms of Zopiclone

Zopiclone is available in two main strengths:

• 3.75 mg tablets – often recommended for elderly patients
• 7.5 mg tablets – standard adult dosage

It is usually taken once daily at bedtime, just before going to sleep.

What is the Maximum Zopiclone Dose in 24 Hours?

According to clinical guidelines and the NHS, the maximum recommended dose of Zopiclone in 24 hours is:

7.5 mg once per night

This dose is meant for healthy adults. For older adults, people with liver or kidney issues, or those who are more sensitive to medications, the maximum dose is 3.75 mg per night.

Can You Take More Than 7.5 mg in a Day?

No. Taking more than 7.5 mg in a 24-hour period is not safe unless specifically directed by a healthcare provider. Exceeding this dose can increase the risk of:

• Over-sedation
• Memory loss
• Breathing difficulties
• Loss of consciousness
• Coma or even death (especially when mixed with alcohol or opioids)

Why is There a Strict Daily Limit for Zopiclone?

Zopiclone’s effects are dose-dependent, and increasing the amount doesn’t just make you sleep longer—it significantly increases central nervous system (CNS) depression. This can lead to:

• Impaired motor function
• Slowed breathing
• Heart rate irregularities

Moreover, the drug has a half-life of 5–6 hours, meaning it stays in your system for a significant amount of time even after you wake up. Double dosing or redosing before it’s cleared from your body can cause drug accumulation and toxicity.

What Happens If You Take Too Much Zopiclone?

Mild Overdose Symptoms:

• Excessive drowsiness
• Lethargy or lack of coordination
• Blurred vision
• Slurred speech
• Nausea or dizziness

Severe Overdose Symptoms:

• Respiratory depression (slow or shallow breathing)
• Hypotension (low blood pressure)
• Hypothermia (low body temperature)
• Unconsciousness or coma
• Death (especially when combined with alcohol or narcotics)

If you suspect that you or someone else has taken too much Zopiclone, call 999 (UK emergency) or visit the nearest A&E immediately.

Can You Take Zopiclone Twice in One Night?

This is a common question among new users. The short answer is: No, you should not take Zopiclone twice in one night.

Even if you wake up in the middle of the night, it’s not safe to take a second dose because:

• You may not get the full 7–8 hours of sleep needed to let the drug clear your system.
• Residual sedation may impair you the next day.
• Taking it too close to waking hours increases the risk of “hangover effects” such as drowsiness, impaired driving, and reduced cognitive function.

Also Read: What Are the Most Common Signs Indicating I Might Have a Sleep Disorder?

Who Should Take a Lower Dose?

Some people may be more vulnerable to the side effects of Zopiclone and should take only 3.75 mg per night, including:

• Adults aged over 65
• People with liver or kidney impairment
• Individuals using other CNS depressants
• People with a history of drug or alcohol dependence

Your doctor will assess your condition and recommend the most appropriate dose for you.

Risk Factors for Overdose or Side Effects

Zopiclone affects everyone differently. These factors may increase your risk of experiencing stronger effects or overdose:

• Age (especially seniors)
• Other medications (especially opioids, antidepressants, or antipsychotics)
• Alcohol consumption
• Poor liver or kidney function
• Sleep apnea or respiratory issues
• Taking it without enough sleep time

Safe Use Guidelines: How to Take Zopiclone Responsibly

1. Take only one dose per night.
2. Ensure you have 7–8 hours available to sleep after taking Zopiclone.
3. Avoid alcohol or any sedating substances.
4. Do not drive or operate heavy machinery the next morning if you feel drowsy.
5. Never mix with opioids or street drugs.
6. Do not crush, chew, or snort tablets.
7. Keep out of reach of children.
8. Do not self-adjust your dose—consult your doctor first.

What If You Miss a Dose?

If you forget to take Zopiclone at bedtime:

• Skip the missed dose if it’s too close to morning.
• Do not double up to compensate for a missed dose.
• Take it only when you can commit to a full night of sleep.

Signs You Might Be Dependent on Zopiclone

Zopiclone is effective for short-term use. Long-term usage may lead to tolerance (needing more to feel the same effect) or dependence.

Signs include:

• Using it for more than 4 weeks continuously.
• Feeling anxious without it.
• Needing higher doses to sleep.
• Craving or thinking about it throughout the day.

If you feel dependent, speak with your doctor about a tapering plan.

Zopiclone Withdrawal Symptoms

Stopping Zopiclone suddenly after long-term use may cause:

• Rebound insomnia
• Anxiety
• Irritability
• Nightmares
• Tremors or sweating
• In rare cases, seizures

Always taper off gradually under professional supervision.

When to See a Doctor

You should contact a doctor if:

• Zopiclone no longer helps you sleep.
• You feel the urge to take more than one dose per night.
• You’ve been using it for over 4 weeks.
• You experience memory issues or mood swings.

Your GP may explore non-drug treatments for insomnia, such as:

• Cognitive Behavioural Therapy for Insomnia (CBT-I)
• Sleep hygiene improvements
• Relaxation techniques

Summary: Know Your Limit, Sleep Safely

Zopiclone is a powerful sleep aid, but it must be used with caution and respect. The maximum dose in 24 hours is 7.5 mg, and taking more can have serious health consequences.

Stick to one dose per night, avoid alcohol and other sedatives, and consult your doctor if your sleep doesn’t improve within a few weeks. Safe sleep begins with smart medication management.

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Always consult your healthcare provider before starting any sleep medication.

Also Read: Can Zopiclone Cause Weight Gain? Understanding the Link Between Sleep Medication and Body Weight