Zopiclone is one of the most commonly prescribed sleep medications in the UK and across the world, used to treat short-term insomnia. It is known for its fast-acting sedative properties and is typically effective within 30 to 60 minutes. However, some users report that Zopiclone is not working even after 2 hours of taking it.

If you’re lying awake wondering why Zopiclone isn’t kicking in, you’re not alone. This article explores the possible reasons why Zopiclone may not be effective for you, what factors can influence its absorption, and what you can do if your sleep aid is not working as expected.

What Is Zopiclone and How Is It Supposed to Work?

Zopiclone is a non-benzodiazepine hypnotic drug used for short-term treatment of insomnia. It works by affecting GABA (gamma-aminobutyric acid) receptors in the brain to calm neural activity and induce sleep.

Typically, Zopiclone 7.5mg is taken shortly before bedtime. The effects usually begin within 30 to 60 minutes, and it helps people fall asleep faster and stay asleep longer. The medication has a half-life of around 5–6 hours, which is why it’s often used for sleep initiation.

So, if you’ve taken Zopiclone and it hasn’t worked even after 2 hours, that’s a clear sign that something isn’t going quite right.

Possible Reasons Why Zopiclone Is Not Working After 2 Hours

a) Zopiclone Tolerance

One of the most common reasons Zopiclone becomes less effective is tolerance. If you’ve been taking Zopiclone regularly—even for a short period—your body may start developing resistance to its sedative effects.

This is known as Zopiclone tolerance, and it can occur in as little as 7–10 days of consistent use.

Signs of tolerance include:

• Zopiclone not kicking in at all
• Taking longer than usual to feel sleepy
• Decreased duration of sleep despite taking the same dose

💡 Medical guidelines generally recommend that Zopiclone be used for no more than 2–4 weeks at a time to avoid dependence and tolerance.

b) Taking Zopiclone After a Heavy Meal

Zopiclone is best taken on an empty stomach or light meal, as heavy or fatty meals can delay the absorption of the drug. If you’ve just had a large dinner or late-night snack, especially high in fat, this can cause the medication to absorb more slowly, reducing its effectiveness.

So, if you’re noticing Zopiclone not working after 2 hours, consider what you ate before taking it.

c) Increased Anxiety or Stress

Sometimes, underlying anxiety or racing thoughts can override the effects of sleep medications. If your mind is very active, Zopiclone may take longer to induce sleep or feel weaker than usual.

Mental tension can create a feedback loop where you’re anxious about not sleeping, which further inhibits the medication’s action.

d) Drug Interactions

If you’re taking other medications—especially antidepressants, antihistamines, or antipsychotics—they can interfere with Zopiclone’s effectiveness or alter its metabolism in the liver.

Always inform your doctor or pharmacist about all the medications or supplements you’re using.

e) Caffeine or Stimulant Intake

Caffeine, nicotine, and certain pre-workout supplements act as central nervous system stimulants. Consuming caffeine in the afternoon or evening may counteract Zopiclone, making it feel like it’s not working.

Also Read: What Is Zopiclone 10mg and How Does It Work?

What to Do If Zopiclone Doesn’t Work

If you’ve taken Zopiclone and it’s not working after 2 hours, do NOT take a second dose unless specifically advised by your doctor. Doubling up can increase the risk of side effects like:

• Excessive daytime drowsiness
• Confusion or memory issues
• Breathing difficulties (especially in elderly or those with sleep apnea)
• Risk of falls or injury

Here’s what you can do instead:

a) Avoid Stimulation

Stay away from screens, lights, and noise. Try deep breathing or light meditation. Zopiclone might still be taking effect subtly.

b) Practice Good Sleep Hygiene

Ensure your bedroom is dark, cool, and quiet. A comfortable environment can help enhance the drug’s effects.

c) Track Patterns

If Zopiclone repeatedly doesn’t work, start a sleep diary. Note down when you took the pill, your meals, mood, and other medications.

This can help identify patterns or reasons why Zopiclone 7.5mg isn’t working as expected.

Can You Build a Resistance to Zopiclone?

Yes. Regular or long-term use of Zopiclone can lead to both tolerance and dependence. This is when your body becomes used to the drug, and it either becomes ineffective or you need higher doses for the same effect—a dangerous path.

This condition is often called Zopiclone resistance, and it’s one reason doctors only prescribe the medication for short durations.

If you’re using Zopiclone for more than 4 weeks and it’s becoming less effective, it’s time to consult your doctor about tapering the dose and exploring alternative sleep aids or therapies.

Alternatives if Zopiclone Stops Working

If Zopiclone is no longer effective for you, consider these alternatives:

a) Short-Term Alternatives

• Melatonin: A natural hormone that regulates sleep cycles
• Promethazine: An antihistamine sometimes used for sleep
• Herbal remedies: Like valerian root, chamomile tea, or magnesium

b) Long-Term Solutions

• CBT-I (Cognitive Behavioural Therapy for Insomnia): Proven to be more effective than sleep pills in the long run
• Sleep restriction therapy
• Relaxation techniques and mindfulness
• Lifestyle changes (e.g., reducing screen time, regular exercise, consistent sleep schedule)

When to Speak to a Doctor

If Zopiclone is not helping you sleep after multiple nights, or you’re starting to rely on it, it’s time to speak with a healthcare provider.

Seek medical advice if:

• You’ve used Zopiclone for more than 2 weeks
• You’re experiencing withdrawal symptoms
• You feel groggy or “hungover” in the mornings
• Your insomnia is tied to anxiety, depression, or other mental health issues

Frequently Asked Questions

Q: Can I take another Zopiclone if the first one didn’t work?
A: No. Taking a second tablet can increase risks of overdose and side effects. Always follow the prescribed dose.

Q: How long does Zopiclone stay in your system?
A: Zopiclone has a half-life of about 5–6 hours, but effects may last longer depending on age, metabolism, and liver function.

Q: Will Zopiclone always work?
A: Not necessarily. Over time, your body may build tolerance, or other health or lifestyle factors may interfere with its effectiveness.

Conclusion: Zopiclone Not Working After 2 Hours? Don’t Panic—Get Informed

Zopiclone is effective for many, but it’s not a one-size-fits-all solution. If you find yourself saying, “Zopiclone is not working after 2 hours,” take it as a signal to reassess how you’re using the medication, what external factors might be at play, and whether tolerance is developing.

Instead of increasing the dose on your own, work with a healthcare professional to explore other options—both medical and behavioural—to improve your sleep long-term.

Also Read: Is Zopiclone a Controlled Drug? Everything You Should Know